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BusparMes
Wysłany: Pon 14:21, 23 Kwi 2007
Temat postu: Online buspar resourse very cheap
Toxicology studies of buspirone yielded the following LD50 values: mice, 655 mg/kg; rats, 196 mg/kg; dogs, 586 mg/kg; and monkeys, 356 mg/kg
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The effect of food upon the bioavailability of buspirone was studied in 8 subjects
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The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months
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BEFORE USING THIS MEDICINE: Some medicines or medical conditions may interact with this medicine
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In man, approximately 95% of buspirone is plasma protein bound, but other highly bound drugs, e
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To achieve an opt
imal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed
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1 mg, 13
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Patients who have previously taken benzodiazepines may be less likely to respond to buspirone than those who have not
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In clinical pharmacology trials, doses as high as 375 mg/day were administered to healthy male volunteers
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Grapefruit and grapefruit juice may interact with BuSpar and lead to potentially dangerous effects
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Post-marketing experience in the US has shown an adverse experie
nce profile similar to that given above
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The effectiveness of buspirone in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials
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Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic
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Do not take the medication in larger amounts, or take it for longer than recommended by your doctor
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Follow the directions on your prescription label
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The efficacy of buspirone has been demonstrate
d in controlled clinical trials of outpatients whose diagnosis roughly corresponds to Generalized Anxiety Disorder (GAD)
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In a study in normal volunteers, concomitant administration of buspirone and haloperidol resulted in increased serum haloperidol concentrations
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Be careful if you drive or do anything that requires you to be awake and alert
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Although it would appear from limited pharmacokinetic and clinical studies that buspirone does not behave differently in the elderly, there is little known about the effects of buspirone in this age group at doses above 30 mg/day
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The safety of buspirone duri
ng pregnancy and lactation has not been established and, therefore, it should not be used in women of childbearing potential or nursing mothers, unless, in the opinion of the physician, the potential benefits to the patient outweigh the possible hazards to the fetus
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Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic
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These tablets have special scored marks on them to make breaking the tablet easy
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5 mg (one half of a tablet), or 5 mg (one third of a tablet)
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Buspirone is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety
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Ask your pharmacist any questions you have about this medication, especially if it is new to you
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, represent akathisia)
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Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear
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Avoid drinking alcohol
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Generally, long-term sequelae of any drug's use can be identified only after several years of marketing
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As this dose was approached, the follow
ing symptoms were observed: nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress
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In a number of studies performed in healthy volunteers, the mean half-life of buspirone ranged from 2 to 3 hours up to approximately 11 hours with considerable variation in individual values
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It may increase some of the side effects caused by BuSpar
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Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor
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Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic
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Additional reports have included rare occurrences of allergic reaction, cogwheel rigidity, dystonic reaction, ecchymosis, emotional lability and tunnel vision
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Buspirone HCl is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety
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The clinical significance of this finding is not clear
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These dosages are 160 to 550 times the recommended human daily dose
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Buspirone does not block the neuronal reuptake of monoamines and, on chronic administration, it does not lead to changes in receptor
density in the models investigated
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The 30-mg tablet also contains iron oxide
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Symptoms of a BuSpar overdose may include nausea, vomiting, dizziness, drowsiness, blurred vision, and stomach pain
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The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months
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7 mg, and 27
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6 mg, 9
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Discuss the use of grapefruit products with your doctor
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Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding
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No deaths have been reported in humans either with deliberate or accidental overdosage of buspirone
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The 15-mg and 30-mg tablets are provided in the DIVIDOSEŽ tablet design
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Do not this medication if you are allergic to BuSpar, or if you ha
ve used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days
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Buspirone is metabolized primarily by oxidation, producing several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine (1-PP)
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The pharmacokinetics of buspirone in patients with hepatic or renal dysfunction, and in the elderly, has also not been clearly established
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Do not take this medication for longer than 4 weeks without your doctors advice
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Do not use this medication with
out telling your doctor if you are breast-feeding a baby
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Be careful if you drive or do anything that requires you to be awake and alert
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Do not give this medication to a child younger than 18 years old
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Therefore, the physician who elects to use buspirone for extended periods should periodically reassess the usefulness of the drug for the individual patient
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Buspirone has an affinity for brain D(2)-dopamine receptors, where it acts as an antagonist and agonist, and for the 5-HT(1A) receptors, where it acts as an agonist
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Addition
al monitoring of your dose or condition may be needed if you are taking fluconazole, itraconazole, ketoconazole, or macrolide antibiotics
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However, in a study of long-term use, 264 patients were treated with buspirone for 1 year without ill effect
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However, the mechanism of action of buspirone remains to be fully elucidated
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Tell your doctor if you are pregnant or plan to become pregnant during treatment
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You may take BuSpar with or without food but take it the same way each time
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Because of the uncontrolled nature of these spontaneous reports, a causal relationship to buspirone treatment has not been determined
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Symptoms of benzodiazepine withdrawal may occur when switching persons from antianxiety medications of the benzodiazepine class (see above) to buspirone since buspirone is not a benzodiazepine
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Buspirone and its metabolites are excreted in milk in rats
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Thus, the 5-mg tablet can also provide a 2
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phenytoin, propranolol and warfarin, are not displaced by buspirone from plasma protein in vitro
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It also lacks the prominent sedative effect that is associated with more typical anxiolytics
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