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Primary [link widoczny dla zalogowanych] Pulmonary Hypertension (PPH)--a rare, frequently fatal disease of the lungs--has been reported to occur in patients receiving a combination of phentermine [link widoczny dla zalogowanych] with fenfluramine or dexfenfluramine. The possibility of an association between PPH and the use of phentermine alone cannot be ruled out; there have [link widoczny dla zalogowanych] been rare cases of PPH in
patients who reportedly have taken phentermine alone. The initial symptom of PPH is usually dyspnea. Other initial symptoms include: angina pectoris, syncope or lower extremity edema. Patients should be advised to report immediately any deterioration in exercise [link widoczny dla zalogowanych] tolerance. Treatment should be discontinued in patients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or lower extremity edema.